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Updated: Aug 23, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
[Case of inflammatory vasculopathy and encephalopathy caused by treatment with tacrolimus]
Adrian Ringelstein1, Katja Bongs, Burkhard Sorge-Hädicke
1Neurologische Klinik mit klinischer Neuro physiologie, Alfried Krupp-Krankenhaus, Essen. neurologie@krupp-krankenhaus.de
Abstract:
The case of inflammatory vasculopathy and encephalopathy caused by treatment with tacrolimus is reported. This 49-year-old woman developed progressive gait ataxia and right-sided hemiparesis after 7 years of tacrolimus therapy for focal sclerosing glomerulonephritis. MRI presented multifocal cerebral lesions with contrast enhancement. Oligoclonal banding was positive. When the treatment with tacrolimus was stopped, the clinical symptoms resolved completely and the MRI findings improved with corticoid monotherapy.
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