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Related Experiment Videos

Endosomes, exosomes and Trojan viruses.

Annegret Pelchen-Matthews1, Graça Raposo, Mark Marsh

  • 1Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK. a.pelchen-matthews@ucl.ac.uk

Trends in Microbiology
|June 30, 2004
PubMed
Summary

Retroviruses, enveloped viruses, may bud from internal cell compartments, not just the plasma membrane. This suggests viral exosomes, utilizing endocytic pathways for assembly and release.

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Area of Science:

  • Virology
  • Cell Biology
  • Molecular Biology

Background:

  • Retroviruses are typically thought to bud from the plasma membrane.
  • Emerging evidence suggests alternative viral assembly and release mechanisms.

Purpose of the Study:

  • To discuss the concept of retroviruses as "viral exosomes".
  • To review evidence for the endocytic pathway's role in viral biogenesis.

Main Methods:

  • Literature review and conceptual discussion.

Main Results:

  • Some enveloped viruses, including retroviruses, utilize the endocytic pathway for assembly and release.
  • Viruses exploit multivesicular body (MVB) biogenesis machinery.

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Conclusions:

  • Retroviruses may be considered "viral exosomes".
  • Endocytic pathway compartments are crucial for MVB and viral particle formation.