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Related Experiment Videos

MMP-9 microsatellite polymorphism and multiple sclerosis.

Nicola Fiotti1, Robert Zivadinov, Nicola Altamura

  • 1Department of Clinical, Morphological and Technological Sciences, University of Trieste, Strada di Fiume, 447, 34149, Cattinara Trieste, Italy. fiotti@units.it

Journal of Neuroimmunology
|June 30, 2004
PubMed
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A genetic variation in matrix metalloproteinase 9 (MMP-9) promoter microsatellites is linked to multiple sclerosis (MS) susceptibility. More CA repeats in MMP-9 are associated with earlier MS onset.

Area of Science:

  • Genetics
  • Neuroimmunology
  • Biochemistry

Background:

  • Matrix metalloproteinase 9 (MMP-9) is implicated in inflammatory processes.
  • Genetic variations in MMP-9 regulatory regions may influence disease susceptibility.
  • Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system.

Purpose of the Study:

  • To investigate the association between a specific polymorphism in the MMP-9 promoter microsatellite and susceptibility to multiple sclerosis.
  • To determine if this polymorphism correlates with clinical characteristics, such as age at disease onset and MRI findings.

Main Methods:

  • Genotyping of the MMP-9 promoter microsatellite polymorphism in 95 MS patients and 95 controls.
  • Comparison of allelic frequencies and carrier prevalence between groups.

Related Experiment Videos

  • Analysis of clinical data, including age at onset and MRI parameters.

    • Main Results:

    • A significantly higher number of CA repeats in the MMP-9 promoter microsatellite was observed in the MS group compared to controls (P<0.0001).
    • Carriers of 22 or more CA repeats had a 3.4-fold increased odds of having MS (OR 3.4, P<0.0001).
    • Patients with >22 CA repeats exhibited an earlier age at disease onset (33+/-10 years) compared to those with fewer repeats (28+/-10 years, P=0.027).
    • No significant differences in main MRI parameters were found between groups.

    Conclusions:

    • The studied polymorphism in the MMP-9 promoter microsatellite is associated with an increased susceptibility to multiple sclerosis.
    • This genetic variation is linked to an earlier age of disease onset in MS patients.
    • The MMP-9 promoter polymorphism does not appear to influence key MRI-defined disease parameters.