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Updated: Aug 23, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
"Big IGF-II"-induced hypoglycemia secondary to gastric adenocarcinoma
L Morbois-Trabut1, F Maillot, A De Widerspach-Thor
1Service de médecine interne A, CHU Bretonneau, 2 boulevard Tonnelle, 37044 Tours Cedex 1, France. maillot@med.univ-tours.fr
Abstract:
Non-islet cell tumor-related hypoglycemia is a rare phenomenon. We report the case of a 63 Year-old man admitted for hemiparesia and a capillary blood glucose of 20 mg/dL. The presence of an immature form of IGF-II that can mimic the effect of insulin, namely "big IGF-II", explained this patient's hypoglycaemia. A moderately differentiated adenocarcinoma of the cardia with metastatic extension to the stomach and the liver was demonstrated. Octreotide failed to control the hypoglycaemia, therefore prednisolone (2 mg/kg per day) and enteral feeding prevented new episodes of severe hypoglycaemia.
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