Related Experiment Video
Updated: Aug 23, 2026

Quantification of Efferocytosis by Single-cell Fluorescence Microscopy
Published on: August 18, 2018
Phosphatidylserine receptor and apoptosis: consequences of a non-ingested meal
1Rheumatology Section, Eric Bywaters Centre, Faculty of Medicine, Imperial College, London, UK. m.botto@imperial.ac.uk
Abstract:
Apoptosis, a physiological process of controlled cell death, is essential during embryonic development and for the maintenance of tissue homeostasis. In recent years the view has emerged that dying cells can provide specific signals that enable recruitment and recognition by phagocytes. Exposure of phosphatidylserine, the best characterized of such signals, allows safe clearance of apoptotic waste without induction of inflammation. Here I re-examine some of the arguments that underpin the importance of these clearance mechanisms in light of recent observations from an animal model that lacks the receptor specific for phosphatidylserine.
More Related Videos
Related Concept Videos
Phagocytosis of Apoptotic Cells
Normal cells contain receptors that prevent them from being recognized by phagocytes.
Apoptosis
The Extrinsic Apoptotic Pathway
Cellular Injury V: Apoptosis and Autophagy
Autophagic Cell Death
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...
Overview of Cell Death
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...

