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Solid tumors of childhood.
Sonal Sharma1, Kiran Mishra, Sarla Agarwal
1Department of Pathology, VP Chest Institute, New Delhi, India. sonald76@sify.com
Indian Journal of Pediatrics
|July 1, 2004
Summary
This study reviewed pediatric tumors in the Indian subcontinent, finding lymphoma and renal tumors most common. Re-classification improved diagnoses, revealing a high rate of epithelial malignancies.
Area of Science:
- Pediatric oncology
- Histopathology
- Cancer research
Background:
- Childhood cancer is a significant cause of mortality.
- Accurate histologic classification is crucial for pediatric malignancies.
- Data from the Indian subcontinent is vital for understanding regional cancer patterns.
Purpose of the Study:
- To conduct a histologic review of pediatric malignancies from the Indian subcontinent.
- To re-classify tumors based on prognostic classifications.
- To identify diagnostic discrepancies and improve classification accuracy.
Main Methods:
- Retrospective review of 472 tumors over 12 years.
- Re-classification of malignant tumors based on current prognostic criteria.
- Utilized immuno-staining for challenging cases.
Main Results:
- 154 malignant tumors were identified out of 472 total.
- Lymphoma and pediatric renal tumors were the most frequent malignant solid tumors.
- Re-classification clarified diagnoses in 14 of 21 initially unclassified cases, including various sarcomas.
Conclusions:
- Histologic review and re-classification enhanced diagnostic accuracy for pediatric tumors.
- The study identified an unexpectedly high incidence (11%) of epithelial malignancies in children.
- Improved classification through immuno-staining is essential for accurate pediatric cancer diagnosis and management.