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Insulin resistance in patients with hypertrophic cardiomyopathy

Kazuo Murakami1, Yuji Shigematsu, Mareomi Hamada

  • 1Department of Internal Medicine, Matsuyama Red Cross Hospital, Matsuyama, Japan.

Circulation Journal : Official Journal of the Japanese Circulation Society
|July 1, 2004
PubMed

Insights

Insulin resistance is present in hypertrophic cardiomyopathy (HCM) patients, even without diabetes or hypertension. This insulin resistance is linked to HCM

Area of Science:

  • Cardiology
  • Metabolic Disorders

Background:

  • Hypertrophic cardiomyopathy (HCM) is a complex cardiac condition.
  • The presence and impact of insulin resistance in HCM are not fully understood.

Purpose of the Study:

  • To investigate insulin resistance in patients with HCM.
  • To determine if insulin resistance correlates with HCM manifestations and clinical outcomes.

Main Methods:

  • Assessed insulin resistance using the Homeostasis Model Assessment (HOMA-IR) in 55 HCM patients, 35 with essential hypertension (EHT), and 15 controls (NC).
  • Analyzed determinants of insulin resistance via multiple regression.
  • Tracked cardiovascular events and mortality during a mean follow-up of 105 months.

Main Results:

  • HCM patients exhibited significantly higher HOMA-IR values compared to EHT and NC groups.
  • Left ventricular pressure gradient, septal thickness, and BMI were independent determinants of insulin resistance in HCM.
  • All 4 sudden deaths in the HCM group occurred in patients with high HOMA-IR.

Conclusions:

  • Insulin resistance is prevalent in HCM patients, independent of diabetes or hypertension.
  • Insulin resistance is associated with the clinical manifestations and adverse outcomes of HCM.
Abstract

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