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Wilms' tumour: presentation and treatment
Arshad Mahmood1, Tariq Ghafoor, Shahida Badsha
1Department of Paediatric Oncology, Combined Military Hospital (CMH), Rawalpindi.
Summary
This study evaluated Wilms' tumour treatment in Pakistan using the United Kingdom Children's Cancer Study Group (UKCCSG) protocol. Outcomes were comparable, but local challenges like resource deficiency require attention.
Area of Science:
- Pediatric Oncology
- Nephrology
Background:
- Wilms' tumour is a common pediatric kidney cancer.
- Standardized treatment protocols improve outcomes.
Purpose of the Study:
- To assess the clinical presentation and treatment outcomes of Wilms' tumour patients managed with the UKCCSG protocol.
- To identify challenges in implementing the protocol in a local setting.
Main Methods:
- An interventional study involving 22 pediatric patients diagnosed with Wilms' tumour.
- Treatment followed the UKCCSG protocol, including surgery, chemotherapy, and radiotherapy.
- Patients were investigated thoroughly before treatment initiation.
Main Results:
- The study included 22 patients (13 boys, 9 girls) aged 4 months to 7 years.
- Tumour stages ranged from I to IV, with 18 cases having favorable histology.
- Overall mortality was 27.3%, with challenges including illiteracy and resource deficiency impacting treatment regularity.
Conclusions:
- Treatment outcomes for Wilms' tumour using the UKCCSG protocol are comparable to international standards.
- Local challenges such as limited resources and patient follow-up regularity need addressing for improved care.