Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonhuman primate models in type 1 diabetes research.

Juan L Contreras1, Cheryl A Smyth, David T Curiel

  • 1Department of Surgery, Division of Transplantation, University of Alabama, Birmingham, AL, USA.

ILAR Journal
|July 2, 2004
PubMed
Summary

Pancreatic islet transplantation (PIT) shows promise for type 1 diabetes, but faces challenges like immunosuppression and tissue shortage. Research is exploring tolerance induction, islet protection, and alternative sources like pigs to advance this therapy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intranasal boosting induces variant-specific responses in SARS-CoV-2 vaccine-imprinted mice.

Nature communications·2026
Same author

AAV vectors for cancer gene therapy.

Advances in cancer research·2026
Same author

Neural stem cell delivery of oncolytic CRAd-S-pk7 immunotherapy for stage 3 ovarian cancer: Dose-regimen studies.

Molecular therapy. Oncology·2026
Same author

Long-acting interleukin-7 improves the efficacy of oncolytic viral therapy in glioblastoma.

Nature communications·2026
Same author

An intranasal adenoviral-vectored vaccine protects against highly pathogenic avian influenza H5N1 in naive and antigen-experienced animals.

Cell reports. Medicine·2026
Same author

Gender Differences in Willingness to Be Evaluated for Living Kidney Donation.

Progress in transplantation (Aliso Viejo, Calif.)·2025

Area of Science:

  • Immunology
  • Endocrinology
  • Regenerative Medicine

Background:

  • Pancreatic islet transplantation (PIT) is a viable therapy for type 1 diabetes, supported by "steroid-free" protocols and improved islet preparation.
  • Significant hurdles remain, including the need for chronic immunosuppression, loss of transplanted islet mass, and limited human donor tissue.

Purpose of the Study:

  • To review current obstacles in pancreatic islet transplantation (PIT) for type 1 diabetes.
  • To highlight strategies for overcoming these barriers, including tolerance induction, islet protection, and alternative donor sources.

Main Methods:

  • Review of existing research on immunosuppression, islet survival, and tissue sourcing for PIT.
  • Discussion of preclinical models, including rodents, large animals (pigs), and primates, for evaluating PIT strategies.

Related Experiment Videos

Main Results:

  • Stable islet allograft function without immunosuppression achieved through tolerance induction in primates.
  • Strategies like gene transfer of antiapoptotic genes enhance islet survival post-transplantation.
  • Pigs identified as a promising alternative islet source due to rapid breeding and genetic engineering potential.

Conclusions:

  • Addressing immunosuppression, islet loss, and tissue scarcity is crucial for routine PIT.
  • Preclinical studies in diverse models, particularly primates, are essential for safe clinical translation of PIT research.