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Updated: Aug 23, 2026

The Establishment of Calvarial Suture-Bony Composite Defects in Rats: A Standardized Model for Suture-Regenerative Therapy Investigation
Published on: May 10, 2024
Granuloma formation around a retained perclose S suture presenting 12 months after implantation
Sagar N Doshi1, Simon Smith, Jonathan N Townend
1Department of Interventional Cardiology, The Queen Elizabeth University Hospital, 3rd Floor Nuffield House, Room 52E, Edgbaston, Birmingham B15 2TH, United Kingdom. sagar.doshi@msnyuhealth.org
Abstract:
Suture-mediated closure devices have become commonplace in interventional and diagnostic femoral catheterization procedures. Although they reduce the time to hemostasis, ambulation, and hospital discharge, they are associated with a greater potential for serious infection compared with manual compression, often with delayed presentation. Scrupulous aseptic procedure and careful technique are vital in reducing complications. Herein a case of sterile granuloma formation around an untrimmed Perclose S suture is reported, which presented 12 months after use of a suture-mediated closure device.