Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Corneal wound healing.

Irene C Kuo1

  • 1Wilmer Eye Institute, Baltimore, Maryland 21236, USA. ickuo@jhmi.edu

Current Opinion in Ophthalmology
|July 3, 2004
PubMed
Summary
This summary is machine-generated.

Corneal wound healing involves fibroblast transformation and intercellular signaling. While pathways may be similar after refractive surgery, outcomes depend on subtle cascade differences, with a unified vision still elusive.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current practice patterns for cleaning tonometry tips and diagnostic/laser lenses.

Journal of cataract and refractive surgery·2026
Same author

Prevention of endophthalmitis with cataract surgery<i>: where are we now 20 years after the ESCRS Study?</i>

The British journal of ophthalmology·2026
Same author

LASIK for Hyperopia: A Report by the American Academy of Ophthalmology.

Ophthalmology·2026
Same author

Medical and surgical interventions for neurotrophic keratopathy.

The Cochrane database of systematic reviews·2025
Same author

Antibiotic prophylaxis for corneal abrasion.

The Cochrane database of systematic reviews·2025
Same author

Topical ophthalmic anesthetics for corneal abrasions: findings from a Cochrane systematic review and meta-analysis.

Communications medicine·2025
Same journal

Laser vision correction (LASIK, PRK, SMILE) with simultaneous accelerated corneal crosslinking.

Current opinion in ophthalmology·2026
Same journal

Traumatic macular hole: observe, operate, or other options.

Current opinion in ophthalmology·2026
Same journal

The evolving role of artificial intelligence in ophthalmology: basic science, translation, and clinical integration.

Current opinion in ophthalmology·2026
Same journal

Editorial: reducing risk for refractive surgery.

Current opinion in ophthalmology·2026
Same journal

Updates on Refractive Surgery: Benefits, Risks, and Costs of Modern Treatment Options.

Current opinion in ophthalmology·2026
Same journal

Corneal Allogeneic Intrastromal Ring Segments for keratoconus - recent evidence and the move to customized and custom shaped CAIRS.

Current opinion in ophthalmology·2026
See all related articles

Area of Science:

  • Ophthalmology
  • Cell Biology
  • Biochemistry

Background:

  • Corneal wound healing is crucial for visual recovery after ocular procedures.
  • Understanding the cellular and molecular mechanisms is key to improving surgical outcomes.
  • Recent advances in refractive surgery have spurred interest in corneal healing processes.

Purpose of the Study:

  • To review current theories on corneal wound healing.
  • Focus on refractive surgery, with brief mentions of incisional surgery and non-surgical conditions.
  • To synthesize knowledge on the complex cascade of corneal repair.

Main Methods:

  • Literature review of recent theories and findings.
  • Analysis of cellular signaling pathways involved in corneal repair.

Related Experiment Videos

  • Examination of the role of extracellular matrix remodeling and free radical damage.

    • Main Results:

    • Corneal wound healing involves fibroblast transformation, intercellular signaling (cytokines, growth factors), matrix metalloproteinases, and antioxidant protection.
    • Potential commonalities exist in wound healing cascades after different corneal surgeries (e.g., LASIK, PRK).
    • Differences in basement membrane disruption influence healing outcomes despite similar cascades.

    Conclusions:

    • Increased interest in corneal wound healing driven by refractive surgery.
    • Key contributors include intercellular signaling, fibroblast changes, matrix remodeling, and antioxidants.
    • A comprehensive, unified understanding of the corneal wound healing cascade is still developing.