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Related Experiment Videos

[Tuberculous meningoencephalitis--own observations].

Aleksander Garlicki1, Urszula Kluba-Wojewoda, Monika Bociaga-Jasik

  • 1Katedra i Klinika Chorób Zakaźnych Collegium Medicum Uniwersytetu Jagiellońskiego ul. Sniadeckich 5, 31-531 Kraków.

Folia Medica Cracoviensia
|July 6, 2004
PubMed
Summary

Tuberculous meningoencephalitis diagnosis in adults relies on clinical signs and cerebrospinal fluid (CSF) analysis. Early treatment with standard chemotherapy leads to favorable outcomes in most cases.

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Microbiology

Context:

  • Tuberculous meningoencephalitis is a severe form of extrapulmonary tuberculosis affecting the central nervous system.
  • Diagnosis can be challenging, often requiring a combination of clinical, laboratory, and imaging findings.

Purpose:

  • To present nine adult cases of tuberculous meningoencephalitis diagnosed and treated between 1993 and 2000.
  • To evaluate diagnostic methods for Mycobacterium tuberculosis in cerebrospinal fluid and clinical outcomes.

Summary:

  • Diagnosis was based on clinical presentation and cerebrospinal fluid (CSF) analysis, including routine tests, microscopy, biological assays, and cultures (Lowenstein-Jensen, Bactec 460 TB).
  • Mycobacterium tuberculosis was identified in CSF by microscopy in one case, biological assay in one, and Bactec 460 TB in four cases.

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  • Pulmonary tuberculosis was noted in 56% of patients on chest X-ray, and 78% had hydrocephalus on CT scans.
  • One patient died, one experienced long-term neurological deficits, while 78% recovered fully after 12 months of standard anti-tuberculosis therapy.

    • Impact:

    • Highlights the importance of comprehensive diagnostic approaches for tuberculous meningoencephalitis.
    • Demonstrates the efficacy of standard chemotherapy regimens in achieving recovery for the majority of affected adults.
    • Underscores the potential for severe neurological complications, including hydrocephalus and paralysis, if left untreated or inadequately managed.