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[Urticaria paradoxically aggraved by H1 antihistamines]
A Catelain1, N Freymond, E Queuille
1Unité Immunologie Clinique et Allergologie, CHU Lyon-Sud, et INSERM U 503, IFR 128, 69495 Pierre-Bénite Cedex, Lyon, France. amandine.lamy-catelain@chu-lyon.fr
Annales De Dermatologie Et De Venereologie
|July 6, 2004
Summary
Some patients experience urticaria (hives) that is worsened by H1 antihistamines, the standard treatment. Anti-leukotrienes were effective for these paradoxical reactions, suggesting histamine may not be the primary mediator.
Area of Science:
- Immunology
- Dermatology
- Allergology
Context:
- H1 antihistamines are the primary treatment for chronic urticaria.
- This study investigates cases where H1 antihistamines paradoxically induce or worsen urticaria.
Purpose:
- To report and analyze cases of urticaria aggravated by H1 antihistamines.
- To explore potential mechanisms behind this paradoxical drug effect.
Summary:
- Five cases of urticaria aggravated by H1 antihistamines were identified.
- Skin tests confirmed a non-IgE dependent mechanism.
- Anti-leukotrienes successfully managed chronic urticaria in 75% of patients.
Impact:
- Challenges the universal efficacy of H1 antihistamines in chronic urticaria.
- Suggests alternative therapeutic targets like leukotrienes for specific patient subgroups.
- Proposes novel hypotheses regarding urticaria pathogenesis, including non-histamine mediators.