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Updated: Jan 28, 2026

Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes
Published on: February 6, 2020
Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity
Lu Chen1, Pedram Hamrah, Claus Cursiefen
1Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA.
Abstract:
There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.
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