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Updated: Aug 23, 2026
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Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System
Published on: May 12, 2013
Simplified surgical placement and stabilization methods for intracerebroventricular cannulas in rat lateral
David H Jho1, Herbert H Engelhard, Altair Juarez
1Department of Surgery, University of Illinois at Chicago, 60612, USA.
Lab Animal
|July 6, 2004
Abstract:
Intracerebroventricular cannulation in rat models is an efficient tool for exploring the effects of substances directly injected into the CNS, bypassing the blood-brain barrier. Techniques for surgically securing the ICV cannula require a balance between ease of application and adequate stability. The authors tested several methods of lateral ventricle cannula stabilization, especially focusing on a comparison of cyanoacrylate gel to cranioplastic cement with an anchoring bone screw.
