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[Physiological leukocytosis].
1Fysiologisk institutt, Instituttgruppe for medisinske basalfag, Blindern, Oslo.
Summary
Physiological leucocytosis, an increase in white blood cells, is primarily mediated by adrenalin. This response to exercise or stress involves leucocyte redistribution from various organs.
Area of Science:
- Physiology
- Hematology
Context:
- Physiological leucocytosis involves an increase in circulating white blood cells (leukocytes).
- This phenomenon occurs in healthy individuals due to physical exercise or elevated adrenaline levels.
- The underlying mechanisms and physiological implications remain largely unknown.
Purpose:
- To review 99 years of research on physiological leucocytosis.
- To identify the primary mediator of this increase in leukocytes.
- To explore the storage and activity of leukocytes during this response.
Summary:
- Adrenaline is identified as the most significant mediator regulating physiological leucocytosis.
- Leukocytes are stored in organs like the lungs, spleen, lymphatic tissue, and bone marrow before entering circulation.
- Evidence suggests altered individual leukocyte activity during physiological leucocytosis.
Impact:
- Clarifies the role of adrenaline in white blood cell count changes.
- Highlights the importance of leukocyte storage sites in this physiological response.
- Provides a comprehensive overview of a poorly understood hematological phenomenon.