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Hepatic pathology in AIDS: a pathological study from Mumbai, India
D N Lanjewar1, R J Rao, S B Kulkarni
1AIDS Research & Control Centre, Grant Medical College and Sir J.J. Group of Hospitals, Byculla, Mumbai, India. arcongov@vsnl.com
HIV Medicine
|July 9, 2004
Summary
Hepatitis in patients with Acquired Immunodeficiency Syndrome (AIDS) is common, with infections being the primary cause. Hepatic tuberculosis is significantly more prevalent in Indian AIDS patients than previously thought.
Area of Science:
- Hepatology
- Infectious Diseases
- Immunology
Background:
- Acquired Immunodeficiency Syndrome (AIDS) can lead to various hepatic complications.
- Understanding the spectrum of liver diseases in AIDS patients is crucial for diagnosis and management.
Purpose of the Study:
- To investigate the range of liver disorders in patients with AIDS.
- To compare the spectrum of hepatic diseases in Indian AIDS patients with findings from developed countries.
Main Methods:
- A retrospective and prospective study was conducted on 171 liver specimens (autopsy and biopsy) from AIDS patients in Mumbai, India.
- Histopathological examination of liver tissues was performed to identify pathological lesions and infectious agents.
Main Results:
- 58% of patients exhibited significant liver pathology, predominantly infection-related.
- The most common hepatic conditions were tuberculosis (41%), cryptococcosis (5%), and cirrhosis (3%).
- Heterosexual transmission was the primary route of HIV infection (95%).
Conclusions:
- AIDS patients have a high incidence of hepatic abnormalities.
- The spectrum of liver disease in Indian AIDS patients differs from that in Western countries, with a notably higher prevalence of hepatic tuberculosis.
- Routine examination of liver specimens for acid-fast bacilli is recommended in AIDS patients.
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