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Updated: Aug 23, 2026
Vessel-Sparing Microsurgical Longitudinal Intussusception Vasoepididymostomy to Treat Epididymal Obstructive Azoospermia
Published on: May 27, 2022
Gonadotropin treatment of an azoospermic patient with a Y-chromosome microdeletion
Helmy A Selman1, Giovanni Cipollone, Liborio Stuppia
1Istituto Europeo Medicina della Riproduzione Abruzzese, Spatocco Hospital, Chieti, Italy. selmanha@yahoo.com
Objective:
To report on the treatment with recombinant FSH of an azoospermic normogonadotropic patient with a Y-chromosome microdeletion.
Design:
Case report.
Setting:
An assisted reproduction center.
Patient(S):
A 32-year-old patient with azoospermia.
Intervention(S):
Histological testicular biopsy, Y-chromosome screening, FSH treatment, and intracytoplasmic sperm injection.
Main Outcome Measure(S):
Fertilization, embryo development, pregnancy, and delivery.
Result(S):
After 6 months of treatment with gonadotropins, a small number of spermatozoa were found in the patient's ejaculate and used for IVF, resulting in a successful twin pregnancy and the delivery of two healthy girls.
Conclusion(S):
In this study, treatment with gonadotropins promoted the spermatogenesis process and led to the production of spermatozoa in a normogonadotropic azoospermic patient.
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Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size. Today,...
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