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Practical aspects of transporter model systems: a case study involving SQV
Yaming Su1, Sung-Hack Lee, Patrick J Sinko
1Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.
Drug Metabolism Reviews
|July 9, 2004
Summary
Drug transporters significantly impact drug absorption and disposition, as demonstrated by saquinavir data. This review highlights models used to predict transporter effects on drug pharmacokinetics.
Area of Science:
- Pharmacology
- Drug Metabolism
- Pharmacokinetics
Background:
- Drug transporters are crucial for drug absorption and disposition.
- Understanding transporter interactions is key for predicting drug behavior.
- Saquinavir (SQV) serves as a case study to illustrate these principles.
Purpose of the Study:
- To provide practical insights into drug transporter interactions.
- To emphasize the application, limitations, and challenges of current in vitro and in vivo models.
- To explore the predictive power of these models for drug pharmacokinetics.
Main Methods:
- In vitro and in vivo experimental models were utilized.
- Case study approach focusing on saquinavir (SQV).
- Review of existing methodologies for assessing drug transporter roles.
Main Results:
- Data confirms the significant role of drug transporters in drug absorption and disposition.
- Various experimental models exist for studying transporter interactions.
- The successful application, limitations, and challenges of these models were highlighted.
Conclusions:
- Drug transporters are critical determinants of drug pharmacokinetics.
- In vitro and in vivo models are valuable tools but have limitations.
- Further refinement of models is needed for accurate pharmacokinetic predictions.