Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatocyte transplantation.

Simon P Horslen1, Ira J Fox

  • 11 Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE 68198-3285, USA.

Transplantation
|July 9, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of multicenter consensus care plans for immunosuppression after pediatric liver transplant: Reducing variability, creating comparative efficacy opportunities.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2026
Same author

AASLD AST NASPGHAN Practice Guideline on pediatric liver transplantation: Post-transplant management.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2026
Same author

OPTN/SRTR 2024 Annual Data Report: Intestine.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

PNPLA3-I148M genetic variant rewires lipid metabolism to drive programmed cell death in human hepatocytes.

JCI insight·2025
Same author

Plasma proteome correlations with liver stiffness in pediatric cholestasis implicate epithelial to mesenchymal transition.

Hepatology communications·2025
Same author

Human-induced pluripotent stem cell-based hepatic modeling of lipid metabolism-associated TM6SF2-E167K variant.

Hepatology (Baltimore, Md.)·2025
Same journal

Filtered or Fried? Rethinking Intraoperative Cell Salvage in Liver Transplantation.

Transplantation·2026
Same journal

Simultaneous Liver-kidney Versus Liver Transplantation Categorized by Pretransplant eGFR: Impact of the 2017 OPTN Policy.

Transplantation·2026
Same journal

Preformed Anti-DQ Alpha Donor-specific Antibodies and the Risk of Antibody-mediated Rejection After Kidney Transplantation.

Transplantation·2026
Same journal

People in Transplantation: Professor Nadey Hakim, MD, PhD, FRCS, FRCSGlas (Hon), FACS, President-Elect of The Transplantation Society.

Transplantation·2026
Same journal

IL-1 Receptor Blockade Modulates Inflammation During Sequential Perfusion in Ex Vivo Porcine Kidneys.

Transplantation·2026
Same journal

Regulatory T Cells Allosensitized Under the Blockade of CD80/CD86-CD28 Costimulation Prolonged Islet Allograft Survival.

Transplantation·2026
See all related articles

Isolated hepatocyte transplantation shows promise for liver disease but faces challenges. A major hurdle is the limited availability of primary human hepatocytes, hindering clinical progress.

Area of Science:

  • Hepatology
  • Transplantation Biology
  • Regenerative Medicine

Background:

  • Isolated hepatocyte transplantation is a potential therapy for severe liver disease.
  • Extensive animal research supports its clinical application.
  • Limited human trials show safety and feasibility, but effectiveness is not conclusive.

Purpose of the Study:

  • To review the current state of hepatocyte transplantation.
  • To identify barriers to clinical advancement.
  • To explore future directions for the technology.

Main Methods:

  • Review of laboratory and clinical experiences with hepatocyte transplantation.
  • Analysis of data from individual cases and small series.
  • Discussion of challenges and potential solutions.

Related Experiment Videos

Main Results:

  • Human hepatocyte transplantation is safe and feasible.
  • Effectiveness data are supportive but not conclusive.
  • A significant shortage of usable primary human hepatocytes is the main limitation.

Conclusions:

  • Hepatocyte transplantation holds untapped potential for liver disease treatment.
  • The scarcity of donor hepatocytes impedes widespread clinical use.
  • Alternative cell sources are needed to advance this therapeutic approach.