Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain function early after stroke in relation to subsequent recovery.

Hoang Nhan1, Kristin Barquist, Kathleen Bell

  • 1Department of Neurology, University of Washington, Seattle, WA, USA.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|July 9, 2004
PubMed
Summary

Early brain activation changes after stroke predict recovery. Increased activation in specific cortical regions, even those remote from the infarct, is identifiable soon after stroke and linked to improved outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Two-Year Retention of Benefits After Paired Vagus Nerve Stimulation in Stroke: Follow-Up of the VNS-REHAB Randomized Clinical Trial.

Neurology·2026
Same author

ENTF Neuromodulation Yields Reduced Disability After Stroke: An Individual Participant-Level Data Meta-Analysis.

Stroke·2026
Same author

Factors Underlying Stroke Recovery Variation by Neighborhood Socioeconomic Status.

JAMA network open·2026
Same author

Advances in Stroke 2026: Recovery and Rehabilitation.

Stroke·2026
Same author

Research Letter: Scoping Review of the Protocol for Responding to and Assessing Patient Assets, Risks, and Experiences (PRAPARE®) to Evaluate Social Determinants of Health Among Persons With TBI.

The Journal of head trauma rehabilitation·2026
Same author

A composite measure of cerebral small vessel disease predicts cognitive change after stroke.

medRxiv : the preprint server for health sciences·2026

Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • Stroke significantly impacts brain function and recovery.
  • Understanding early cortical changes is crucial for predicting stroke recovery and guiding interventions.

Purpose of the Study:

  • To characterize brain activation and perfusion in cortical regions early after stroke.
  • To identify patterns of functional magnetic resonance imaging (fMRI) changes during stroke recovery.
  • To correlate early brain activation with clinical outcome.

Main Methods:

  • Serial perfusion-weighted imaging and fMRI during finger movement in stroke patients (n=8) and controls (n=7).
  • Measurements taken at two time points: early after stroke (mean 16 days) and 3.5 months later.
  • Analysis focused on changes in regional activation volumes and perfusion in sensorimotor cortex.

Related Experiment Videos

Main Results:

  • Stroke patients showed varied fMRI changes during recovery, with increased activation in 5/8 patients.
  • Early activation foci that enlarged during recovery were often already present and could be outside the infarct's vascular territory.
  • Sensorimotor cortex perfusion was generally preserved in the stroke hemisphere early after stroke.
  • Improved clinical outcomes correlated with increased activation in bilateral sensory cortices.

Conclusions:

  • Cortical activation patterns predictive of stroke recovery are often identifiable early, even if remote from the infarct.
  • Early perfusion is typically not compromised in relevant cortical areas, suggesting it doesn't hinder recovery-related activation.
  • These findings support the potential for early restorative interventions within weeks of stroke.