Related Experiment Videos
Intestinal obstruction associated with oral midodrine
Atul Pathak1, Pascaline Debats, Michel Galinier
1Service de Pharmacologie Clinique et Centre Midi-Pyrénées de Pharmacovigilance, de Pharmacoépidémiologie et d'Information sur le Médicament, Faculté de Médecine, Toulouse, France.
Summary
This case report details severe ileus potentially caused by midodrine, a medication that may inhibit intestinal motility. Further research is needed to understand this adverse drug reaction.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Midodrine is a medication used to treat symptomatic orthostatic hypotension.
- Intestinal motility disorders can cause significant patient morbidity.
Observation:
- A patient experienced severe ileus, a condition characterized by the cessation of intestinal motility.
- The onset of ileus was temporally associated with the administration of midodrine.
Findings:
- This case is the first to suggest midodrine may have an inhibitory effect on intestinal motility.
- Potential pharmacological mechanisms for midodrine-induced ileus are explored.
Implications:
- Clinicians should be aware of the potential for midodrine to cause or exacerbate ileus.
- This finding may prompt further investigation into the gastrointestinal effects of midodrine.