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Metabolic Dysfunction-Associated Steatotic Liver Disease: An Underrated and Emerging Cardiovascular Risk Factor
Pierre Sabouret1, Domenico Mario Giamundo2, Giuseppe Ando3
1Heart Institute, Pitié-Salpetriere Hospital, ACTION Study Group, Sorbonne University, Paris, France.
Anatolian Journal of Cardiology
|July 27, 2026
Summary
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global liver condition strongly linked to cardiovascular disease (CVD). Addressing MASLD is crucial for reducing heart complications and improving patient outcomes.
Area of Science:
- Hepatology
- Cardiology
- Metabolic Disorders
Background:
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally.
- MASLD is increasingly recognized as a significant driver of cardiovascular morbidity and mortality.
- It represents a systemic metabolic disorder intrinsically linked to cardiovascular disease (CVD).
Purpose of the Study:
- To review the epidemiological and pathophysiological connections between MASLD and CVD.
- To explore MASLD's role in conditions like atherosclerosis, coronary artery disease, and heart failure.
- To discuss clinical implications for cardiovascular risk assessment and management in MASLD patients.
Main Methods:
- Systematic review of current scientific evidence.
- Analysis of epidemiological data linking MASLD and cardiovascular outcomes.
- Examination of pathophysiological mechanisms connecting liver and cardiovascular systems.
Main Results:
- MASLD is independently associated with increased cardiovascular risk, beyond traditional risk factors.
- Mechanisms include insulin resistance, inflammation, dyslipidemia, endothelial dysfunction, and prothrombotic states.
- Liver fibrosis severity correlates with heightened cardiovascular risk.
Conclusions:
- MASLD is a systemic disease with profound cardiovascular implications.
- Integrated management strategies are essential for reducing both hepatic and cardiac complications.
- Early risk stratification and multidisciplinary care are vital for patients with MASLD.
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