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Updated: Aug 23, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
The thyroglobulin gene as the first thyroid-specific susceptibility gene for autoimmune thyroid disease
1Division of Endocrinology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA. Yaron.Tomer@mssm.edu
Abstract:
Recent linkage and association studies provide evidence for thyroglobulin (Tg) being an autoimmune thyroid disease (AITD) susceptibility gene. The Tg locus has been reported to be linked with AITD in two independent studies, and further analysis demonstrated that markers within the Tg gene were associated with AITD. Furthermore, missense single-nucleotide polymorphisms (SNPs) in the Tg gene were shown to be associated with autoimmune thyroiditis in both mice and humans. If Tg is confirmed as a susceptibility gene for AITD, it could provide a novel therapeutic target.
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