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Fibrin gel limits intra-abdominal adhesion formation
G W Chmielewski1, J M Saxe, S A Dulchavsky
1Department of Surgery, Wayne State University School of Medicine, Detroit, Michigan.
The American Surgeon
|September 1, 1992
Summary
Autologous fibrin gel (FG) reduced abdominal adhesions, particularly at the colon and incision sites, in a rabbit model. This effect was independent of its hemostatic properties, suggesting a novel anti-adhesion mechanism.
Area of Science:
- Biomedical Engineering
- Surgical Research
- Wound Healing
Background:
- Autologous fibrin gel (FG) shows promise for hepatic injury.
- The role of fibrin compounds in intra-abdominal adhesion formation remains debated.
Purpose of the Study:
- To investigate the efficacy of autologous fibrin gel in preventing intra-abdominal adhesions.
- To evaluate the mechanism of action of fibrin gel in adhesion formation.
Main Methods:
- A rabbit devascularization model was used, inducing uterine horn abrasion and devascularization.
- Rabbits received either fibrin gel (FG) or saline control (C).
- Adhesion grading and peritoneal lavage for red blood cell (RBC) analysis were performed at one week.
Main Results:
- Fibrin gel significantly reduced adhesions at the colon and abdominal incision sites compared to controls (P < 0.05).
- No significant difference in adhesion grades was observed for the small bowel, bladder, or uterus.
- Peritoneal lavage showed no significant difference in RBC counts between groups, indicating a non-hemostatic mechanism.
Conclusions:
- Autologous fibrin gel effectively reduces specific intra-abdominal adhesions, notably incisional and colonic.
- The anti-adhesion effect of fibrin gel is mediated through a non-hemostatic pathway.
- Further research into fibrin gel's anti-adhesion properties is warranted.