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Updated: Aug 23, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
[Hepatocellular carcinoma without cirrhosis in a patient with nonalcoholic steatohepatitis]
Rabia Bencheqroun1, Christophe Duvoux, Alain Luciani
1Service d'Hépatologie et de Gastroentérologie, Hôpital Henri Mondor, Créteil.
Abstract:
All cases of hepatocellular carcinoma reported thus for in patients with nonalcoholic steatohepatitis have occurred on preexisting cirrhosis. We report the case of a 68-Year-old male patient with nonalcoholic steatohepatitis who developed hepatocellular carcinoma in the absence of cirrhosis. This observation suggests a possible relationship between nonalcoholic steatohepatitis and/or excess body weight, and hepatocellular carcinoma independent of cirrhosis. Further epidemiological studies are needed to evaluate the incidence of this association.
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