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Unzipping of DNA with correlated base sequence
A E Allahverdyan1, Zh S Gevorkian, Chin-Kun Hu
1Institute for Theoretical Physics, Valckenierstraat 65, 1018 XE Amsterdam, The Netherlands. armena@science.uva.nl
Abstract:
We consider force-induced unzipping transition for a heterogeneous DNA model with a correlated base sequence. Both finite-range and long-range correlated situations are considered. It is shown that finite-range correlations increase stability of DNA with respect to the external unzipping force. Due to long-range correlations the number of unzipped base pairs displays two widely different scenarios depending on the details of the base sequence: either there is no unzipping phase transition at all, or the transition is realized via a sequence of jumps with magnitude comparable to the size of the system. Both scenarios are different from the behavior of the average number of unzipped base pairs (non-self-averaging). The results can be relevant for explaining the biological purpose of correlated structures in DNA.
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