Effect of Nissen fundoplication on esophageal motor function

The effect of Nissen fundoplication on the compromised esophageal body function in patients with gastroesophageal reflux disease is poorly understood. Stationary manometry of the distal esophageal body was performed in 50 normal volunteers and compared with that in 40 patients with increased esophageal acid exposure. The studies were performed before and 11 to 68 months (median, 30 months) after successful reflux control and healing of acute mucosal injury with Nissen fundoplication. Before the operation, patients had a lower mean amplitude of contractions, higher prevalence of low amplitude, and interrupted and simultaneous contractions in the distal esophagus compared with normal volunteers. Nissen fundoplication restored the lower esophageal sphincter to normal, increased contraction amplitude, and reduced the prevalence of low-amplitude contractions but did not improve contraction amplitude in patients with a mean amplitude below 35 mm Hg. Fundoplication improves esophageal contraction amplitude but should be performed before the mean contraction amplitude falls below 35 mm Hg.