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Related Experiment Videos

Intravascular schistosomes and complement.

Patrick J Skelly1

  • 1Department of Biomedical Sciences, Division of Infectious Diseases, Tufts University School of Veterinary Medicine, 200 Westboro Road, Grafton, MA 01536, USA. Patrick.Skelly@Tufts.edu

Trends in Parasitology
|July 13, 2004
PubMed
Summary
This summary is machine-generated.

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Schistosomes evade host immunity using complement regulatory proteins. Their in vivo protective role against the complement cascade remains unclear.

Area of Science:

  • Immunology
  • Parasitology
  • Molecular Biology

Background:

  • Schistosomes inhabit the bloodstream, facing host immune defenses like complement.
  • Parasites employ regulatory proteins, some host-derived, to inhibit complement.
  • Known proteins include C2-, C3-, C8-, and C9-binding proteins, and an Fc receptor.

Purpose of the Study:

  • To investigate the in vivo protective role of schistosome complement regulatory proteins.
  • To clarify how these proteins contribute to parasite survival against host immunity.

Main Methods:

  • The abstract does not specify methods.
  • Further research is needed to determine the in vivo mechanisms.

Main Results:

Related Experiment Videos

  • Evidence suggests schistosomes possess proteins that bind complement components (C2, C3, C8, C9) and immunoglobulin.
  • The functional significance of these proteins in vivo is currently unknown.

    • Conclusions:

    • Schistosomes have multiple strategies to interfere with the complement system.
    • The in vivo relevance of these complement evasion mechanisms requires further investigation.