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Platelet count and platelet parameters in hemoglobin E carriers.

Suphan Soogarun1, Sanong Sirimongkolsakul, Viroj Wiwanitkit

  • 1Department of Clinical Microscopy, Faculty of Allied Health Science, Chulalongkorn University, Bangkok 10330, Thailand.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|July 13, 2004
PubMed
Summary

Hemoglobin E carriers in Thailand do not show increased platelet counts or altered platelet parameters. This study found no evidence of quantitative platelet disorders in individuals with hemoglobin E (HbE) compared to healthy subjects.

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Area of Science:

  • Hematology
  • Genetics
  • Thrombosis

Background:

  • Hemoglobinopathies, particularly hemoglobin E (HbE) disorder, are prevalent in Thailand.
  • Previous research suggests potential coagulation abnormalities and thrombotic risks in patients with hemoglobin disorders, possibly linked to thrombocytosis.

Purpose of the Study:

  • To investigate platelet count and parameters in individuals carrying the hemoglobin E trait.
  • To compare these parameters between HbE carriers and healthy subjects to assess potential quantitative platelet disorders.

Main Methods:

  • A comparative study involving 57 healthy subjects, classified by hemoglobin electrophoresis.
  • The study group included 46 healthy individuals and 11 individuals identified as HbE carriers.
  • Platelet count and various platelet parameters were analyzed and compared between the two groups.

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Main Results:

  • No statistically significant differences were observed in platelet count or platelet parameters between HbE carriers and healthy subjects (p > 0.05).
  • Despite some reports suggesting qualitative platelet changes in HbE disorders, this study found no quantitative platelet abnormalities.
  • A trend toward increased platelet count in HbE carriers was not detected.

Conclusions:

  • Hemoglobin E carriers do not exhibit quantitative platelet count or parameter differences compared to healthy individuals.
  • The findings do not support the hypothesis of increased thrombotic risk due to thrombocytosis in HbE carriers based on platelet count.
  • Further research may be needed to explore potential qualitative platelet alterations in hemoglobin E disorders.