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Related Experiment Videos

Mucosal drug delivery: membranes, methodologies, and applications.

Yifan Song1, Yiping Wang, Rashmi Thakur

  • 1Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, Lab for Drug Delivery, Newark, New Jersey 07103, USA.

Critical Reviews in Therapeutic Drug Carrier Systems
|July 14, 2004
PubMed
Summary

Mucosal drug delivery offers a noninvasive alternative for systemic drugs, enhancing absorption via nasal and buccal routes. Various agents can improve transmucosal drug delivery efficacy and bioavailability.

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Area of Science:

  • Pharmacology
  • Drug Delivery Systems
  • Biomedical Engineering

Background:

  • Novel drug delivery systems are crucial for effective systemic therapies.
  • Mucosal drug delivery presents a promising noninvasive administration route.
  • This approach bypasses hepatic first-pass metabolism, improving drug bioavailability.

Purpose of the Study:

  • To explore transmucosal drug delivery as a viable alternative for systemic drugs.
  • To identify and evaluate agents that enhance transmucosal drug absorption.
  • To review the efficacy and safety profiles of various transmucosal enhancers.

Main Methods:

  • Investigated various mucosal absorptive surfaces including nasal, buccal, ocular, vaginal, and rectal routes.
  • Focused on nasal and buccal mucosae as the most promising delivery pathways.

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  • Examined the impact of drug properties, mucosal state, and delivery systems on bioavailability.
  • Evaluated enhancers such as cyclodextrins, bile salts, surfactants, microspheres, liposomes, and bioadhesives.

    • Main Results:

    • Nasal and buccal mucosae demonstrated significant potential for transmucosal drug delivery.
    • Bioavailability is influenced by the condition of the mucosa and characteristics of the drug and delivery system.
    • Several agents, including cyclodextrins and liposomes, were identified as effective enhancers.
    • Mechanisms, efficacy, and toxicity of enhancers were studied in preclinical and clinical models.

    Conclusions:

    • Transmucosal drug delivery, particularly via nasal and buccal routes, offers significant advantages for systemic drug administration.
    • The efficacy of transmucosal delivery can be substantially improved using various enhancer agents.
    • Further research into enhancer mechanisms and safety is essential for optimizing transmucosal therapies.