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Neocortical volume decrease in relapsing-remitting MS patients with mild cognitive impairment.

M P Amato1, M L Bartolozzi, V Zipoli

  • 1Department of Neurology, University of Florence, Viale Morgagni, 85-50134 Florence, Italy. mariapia.amato@unifi.it

Neurology
|July 14, 2004
PubMed
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Cognitively impaired patients with early relapsing-remitting multiple sclerosis (MS) show neocortical atrophy, linked to deficits in memory and attention. This suggests gray matter changes contribute to cognitive decline even in early MS stages.

Area of Science:

  • Neuroimaging
  • Neurology
  • Cognitive Science

Background:

  • Relapsing-remitting multiple sclerosis (RRMS) can lead to cognitive impairment.
  • Early detection of neocortical changes is crucial for understanding MS progression.

Purpose of the Study:

  • To investigate neocortical volume changes in early RRMS.
  • To determine the relationship between these changes and cognitive function.

Main Methods:

  • Conventional MRI was used to measure normalized cortical volumes (NCVs) in 41 RRMS patients and 16 controls.
  • Automated analysis tools quantified cortical brain volumes.
  • Neuropsychological testing assessed cognitive performance in MS patients.

Main Results:

Related Experiment Videos

  • The overall MS group had lower NCVs than controls.
  • Cognitively impaired MS patients (MS-ci) showed significantly lower NCVs than cognitively preserved MS patients (MS-cp) and controls.
  • NCVs correlated positively with verbal memory, verbal fluency, and attention/concentration in MS-ci patients.

Conclusions:

  • Cortical atrophy is present in cognitively impaired MS patients.
  • Gray matter pathology is associated with cognitive impairment in early MS.
  • Neocortical changes may contribute to cognitive decline from the earliest stages of MS.