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Updated: Aug 23, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
Allergic contact dermatitis to methylprednisolone aceponate in a topical corticosteroid
Jennifer Cahill1, Rosemary Nixon
1Occupational Dermatology Research and Education Centre, Skin and Cancer Foundation Victoria, Victoria, Australia.
Abstract:
A 42-year-old registered nurse presented with a recurrent history of multifactorial hand dermatitis, which had ceased to respond to the topical corticosteroid that she was using. Patch testing revealed strong reactions to both Advantan Fatty Ointment (Commonwealth Serum Laboratories, Melbourne, Australia), and its active ingredient, methylprednisolone aceponate. Methylprednisolone aceponate is one of the more sensitizing topical corticosteroids and is becoming increasingly recognized as a significant allergen.
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