Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Pathology and pathogenesis of propionic acidemia].

P F Mahnke¹, H Weidenbach

¹Abteilung für Kinderpathologie, Universität Leipzig, Deutschland.

Zentralblatt Fur Pathologie

|June 1, 1992

Summary

Propionic acidemia causes brain damage and protein deposits in organs and tissues. This study examines pathomorphological changes in affected newborns, detailing the underlying pathogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Determination of (13)CO(2)/(12)CO(2) Ratio by IRMS and NDIRS.

Isotopes in environmental and health studies·2011

Same author

[A 17 year old adolescent with chronic neutropenia, recurrent infections, severe dysphagia and peroneus palsy].

Der Internist·2009

Same author

Bile synthesis in rat models of inflammatory bowel diseases.

European journal of clinical investigation·2007

Same author

[Noninvasive brush biopsy as an innovative tool for early detection of oral carcinomas].

Mund-, Kiefer- und Gesichtschirurgie : MKG·2004

Same author

[82-year old patient with hyperostosis frontalis, prognathism, makroglossia and cutis gyrata. Acromegaly].

Der Internist·2004

Same author

[Effect of cellular growth factors on hepatocytes in experimental infection--regulation of NF-kappa B and glutathione homeostasis].

Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress·2003

Area of Science:

Biochemistry
Pathology
Genetics

Background:

Propionic acidemia is an inherited metabolic disorder.
It leads to toxic metabolite accumulation.
Early diagnosis and understanding pathogenesis are crucial.

Observation:

This paper details pathomorphological alterations in a male newborn with propionic acidemia.
International literature cases were evaluated.
The study focuses on the pathogenesis of the disease.

Findings:

Predominant findings include degenerative alterations in the brain.
Proteinaceous deposits were observed in the liver, kidney, skin, and fatty tissue.
These findings highlight the systemic impact of propionic acidemia.

Implications:

Understanding these pathological findings aids in diagnosing propionic acidemia.
This research contributes to the knowledge of metabolic disorder pathogenesis.
Further research can explore therapeutic strategies targeting these alterations.

Related Experiment Videos