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Hyperthyroidism during lithium therapy for depression
Summary
Lithium therapy for depression can uncommonly cause hyperthyroidism, a condition often masked by lithium
Area of Science:
- Endocrinology
- Psychiatry
Background:
- Lithium is a common treatment for bipolar disorder.
- Hypothyroidism is a known side effect of lithium therapy.
- Hyperthyroidism during lithium therapy is rare but reported.
Purpose of the Study:
- To document cases of hyperthyroidism in patients on lithium therapy.
- To highlight the potential underdiagnosis of lithium-induced hyperthyroidism.
Main Methods:
- Case series reporting three patients.
- Literature review on lithium and thyroid dysfunction.
Main Results:
- Three patients on lithium (7 months to 17 years) developed hyperthyroidism.
- Symptoms included heat intolerance, palpitations, and tremor.
- Radioactive iodine therapy was successful for these cases.
Conclusions:
- Hyperthyroidism during lithium therapy may be underdiagnosed and underreported.
- Clinicians should consider hyperthyroidism in patients on lithium presenting with relevant symptoms.
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