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Published on: February 16, 2016
Short-term effects of coronary angiographic contrast agents on thyroid function
T M Koroscil1, P R Pelletier, J W Slauson
1Department of Endocrinology, Wright-Patterson Air Force Base, Medical Center, Wright-Patterson AFB, Ohio 45433-5529, USA.
Summary
Iodine-containing contrast agents like Omnipaque and Renografin, used in coronary angiography, do not significantly alter thyroid hormone levels in patients with normal thyroid function. No cases of hyperthyroidism were observed post-procedure.
Area of Science:
- Endocrinology
- Radiology
- Cardiology
Background:
- Thyroid hormone levels are crucial for metabolic regulation.
- Iodinated contrast agents are frequently used in cardiac imaging.
- Potential impact of contrast agents on thyroid function requires investigation.
Purpose of the Study:
- To evaluate the effect of two specific iodinated contrast agents on thyroid hormone concentrations.
- To assess the safety of Omnipaque and Renografin regarding thyroid function post-coronary angiography.
Main Methods:
- Prospective study of 56 patients undergoing cardiac catheterization.
- Measurement of thyroid hormones (TSH, T4, T3 uptake, Free T4 index) at baseline, day 1, and day 7.
- Inclusion of patients with no prior thyroid disease and normal thyroid examinations.
Main Results:
- No significant changes in thyroid-stimulating hormone (TSH), total thyroxine, triiodothyronine resin uptake, free thyroxine index, or total triiodothyronine were observed.
- A minor, transient increase in TSH was noted in three patients at 7 days post-angiography.
Conclusions:
- Iodinated contrast agents administered during cardiac catheterization do not induce hyperthyroidism.
- Patients with normal baseline thyroid function can safely undergo procedures using these contrast agents without significant thyroid hormone disruption.
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