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Related Experiment Videos

[Transient visual decrease after photodynamic therapy].

S Mennel1, N Hausmann, C H Meyer

  • 1Klinik für Augenheilkunde, Philipps-Universität, Marburg. stefan.mennel@lycos.com

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|July 15, 2004
PubMed
Summary
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Photodynamic therapy (PDT) can cause a temporary hyperopic shift and reduced visual acuity in patients. This visual disturbance is primarily linked to transient macular edema following treatment.

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Diseases

Background:

  • Photodynamic therapy (PDT) is a treatment that can lead to temporary visual acuity decrease post-procedure.
  • Understanding the causes of this visual disturbance is crucial for patient management.

Purpose of the Study:

  • To investigate the causes of transient visual acuity decrease after photodynamic therapy (PDT).
  • To quantify refractive changes and axial length alterations post-PDT.
  • To correlate optical coherence tomography (OCT) findings with visual outcomes.

Main Methods:

  • Evaluated best corrected visual acuity (VA), refraction, and A-scan ultrasound biometry before and after PDT.
  • Performed linear and 3-D optical coherence tomography (OCT) in select cases.

Related Experiment Videos

  • Followed 53 PDT treatments in 24 patients.
  • Main Results:

    • A mean hyperopic shift of +0.35 diopters was observed in 43% of treatments by day 2 post-PDT, reducing to +0.07 dpt by week 1.
    • Visual acuity remained stable or improved in 68% of patients at day 2, with a decrease noted in 32% initially, declining to 23% by week 1.
    • A-scan biometry showed a mean axial length reduction of 0.13 mm at day 2, correlating with the hyperopic shift. OCT revealed transient macular edema.

    Conclusions:

    • A transient hyperopic shift occurs in 43% of patients by day 2 post-PDT.
    • The observed decrease in visual acuity is mainly attributed to this transient hyperopic shift.
    • Transient macular edema, visualized by OCT, may be related to the hyperopic shift following PDT.