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Updated: Aug 23, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Improving cancer therapy through p53 management

Susan Haupt1, Ygal Haupt

  • 1Department of Pharmaceutics, School of Pharmacy, Hadassah Medical School, The Hebrew University, Jerusalem, Israel.

Cell Cycle (Georgetown, Tex.)
|July 16, 2004
PubMed

Insights

Restoring the tumor suppressor p53

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The tumor suppressor p53 is crucial for cellular responses to stress.
  • Loss of p53 function can lead to cancer development.
  • Restoring p53 activity is a therapeutic strategy for malignancy.

Purpose of the Study:

  • To review promising p53-based cancer therapies.
  • To discuss strategies currently in clinical trials.
  • To explore innovative p53-targeting concepts.

Main Methods:

  • Review of clinical trials involving p53-based therapies.
  • Analysis of novel therapeutic concepts targeting p53.
  • Synopsis of methods to restore or mimic p53 functions.

Main Results:

  • Several p53-based strategies are under clinical investigation.
  • Innovative approaches aim to re-engage p53 in cancer cells.
  • Gene therapy and p53 reactivation show therapeutic potential.

Conclusions:

  • p53-based strategies represent a promising avenue for cancer treatment.
  • Restoring wild-type p53 function is a key therapeutic goal.
  • Ongoing research continues to develop novel p53-targeting therapies.

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