Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Negative regulators of programed cell death.

R E Ellis1

  • 1Laboratory of Molecular Biology, University of Wisconsin, Madison 53706.

Current Opinion in Genetics & Development
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"It's Time to see What I Can Do": A Mixed-Methods Investigation into Trajectories of Resilience in Adolescents during the COVID-19 Pandemic.

Journal of child & adolescent trauma·2024
Same author

Mechanically-induced osteophyte in the rat knee.

Osteoarthritis and cartilage·2020
Same author

The influence of osteophyte depiction in CT for patient-specific guided hip resurfacing procedures.

International journal of computer assisted radiology and surgery·2015
Same author

Wide-angle ITER-prototype tangential infrared and visible viewing system for DIII-D.

The Review of scientific instruments·2014
Same author

Analyzing shoulder translation with navigation technology.

International journal of computer assisted radiology and surgery·2012
Same author

Integrated Intensity Measurements of Carbon Dioxide Bands in the 4.82-micro and 5.17-micro Regions.

Applied optics·2010
Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
Same journal

Cis-regulatory strategies in developmental patterning.

Current opinion in genetics & development·2026
Same journal

GABAergic neuron fate specification and lineage allocation: from development to disorder.

Current opinion in genetics & development·2026
See all related articles

Cell death regulation is crucial during animal development. Genes suppressing programmed cell death are vital, and their disruption can lead to disease.

Area of Science:

  • Developmental Biology
  • Genetics
  • Cell Biology

Background:

  • Programmed cell death (apoptosis) is a fundamental process during animal development.
  • Newly identified genes actively suppress the cell-death program in various species.
  • These suppressor genes are critical for controlling cellular demise.

Purpose of the Study:

  • To investigate the role of cell-death suppressing genes in animal development.
  • To understand the regulatory mechanisms of cell death pathways.
  • To explore the link between disrupted cell death regulation and disease.

Main Methods:

  • Comparative genomics analysis of cell-death suppressor genes.
  • Molecular biology techniques to study gene function.
  • In vivo studies in model organisms.

Related Experiment Videos

Main Results:

  • Identification and characterization of key genes involved in suppressing programmed cell death.
  • Elucidation of the regulatory network controlling cell death.
  • Demonstration of the link between genetic defects in these pathways and disease pathogenesis.

Conclusions:

  • Genes that suppress programmed cell death are essential regulators during development.
  • Dysregulation of these genes has significant implications for health and disease.
  • Further research into these pathways could reveal novel therapeutic targets.