Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Thyroid hormone metabolism and action].

Josef Köhrle1

  • 1Institut für Experimentelle Endokrinologie und Endokrinologisches Forschungs-Centrum der Charité EnForCé, Campus Charité Mitte, Charité Universitätsmedizin Berlin, Germany. josef.koehrle@charite.de

Zeitschrift Fur Arztliche Fortbildung Und Qualitatssicherung
|July 17, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative Evaluation of hiPSC-Derived Brain Organoids as Platforms for Assessing Thyroid Hormone System Disrupting Chemicals.

Cells·2026
Same author

Maternal exposure to the thyroperoxidase-inhibiting pesticide amitrole induces hypothyroidism and developmental neurotoxicity in the rat brain.

Frontiers in endocrinology·2026
Same author

Examining <i>in vivo</i> effects of silychristin, a potent <i>in vitro</i> inhibitor of thyroid hormone transporter MCT8.

Frontiers in toxicology·2026
Same author

Novel Deiodinase 2-Selective Inhibitors-Possible Reference Substances for Regulatory <i>In Vitro</i> Tests for Endocrine Disruptors and Drugs Targeting T3-Dependent Processes.

Thyroid : official journal of the American Thyroid Association·2026
Same author

Not So Fast: Incomplete Assumptions of Adverse Thyroid Effects from PFAS Exposure.

Environmental science & technology·2025
Same author

EndoCompass Project: Research Roadmap for Thyroid Endocrinology.

Hormone research in paediatrics·2025

Thyroid hormone deiodination by iodothyronine deiodinases regulates hormone activity. Disturbances in deiodinase expression impact thyroid hormone homeostasis, affecting development and adult physiology.

Area of Science:

  • Biochemistry
  • Endocrinology
  • Molecular Biology

Context:

  • Thyroid hormones are crucial for development and metabolism.
  • Thyroid hormone activity is modulated by deiodination and other metabolic pathways.
  • Iodothyronine deiodinases (selenium-containing enzymes) play a key role in thyroid hormone metabolism.

Purpose:

  • To explore the mechanisms of thyroid hormone metabolism, focusing on reductive deiodination.
  • To understand the role of iodothyronine deiodinases in regulating thyroid hormone activity.
  • To investigate how alterations in deiodinase expression affect thyroid hormone homeostasis.

Summary:

  • Reductive deiodination of thyroid hormones at phenolic and tyrosyl rings activates or inactivates thyromimetic activity.

Related Experiment Videos

  • Alterations in iodothyronine deiodinase activity are observed during development and in adult tissues.
  • Pathophysiological changes in deiodinase expression disrupt thyroid hormone homeostasis, with therapeutic relevance.
  • Metabolism via conjugation or ether bridge cleavage also contributes to hormone activity or degradation.
  • Multiple components, including T3 receptors and transport proteins, mediate thyroid hormone's pleiotropic actions.

    • Impact:

    • Provides insights into the regulation of thyroid hormone activity.
    • Highlights the significance of deiodinases in thyroid hormone homeostasis.
    • Offers potential targets for therapeutic interventions in thyroid-related disorders.