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Erythema multiforme associated with candesartan cilexetil
A Ahsan Ejaz1, John S Walsh, Andrew Wasiluk
1Division of Nephrology and Hypertension and the Department of Dermatology, Mayo Clinic, Jacksonville, FL, USA. tigris@att.net
Southern Medical Journal
|July 17, 2004
Summary
Candesartan cilexetil, an antihypertensive, rarely causes adverse effects. This report details a first-time case of erythema multiforme linked to candesartan cilexetil in a hypertensive patient.
Area of Science:
- Cardiology
- Dermatology
- Pharmacology
Background:
- Hypertension management often involves multiple medications.
- Candesartan cilexetil is an angiotensin II receptor antagonist used for hypertension.
- Adverse effects of candesartan cilexetil are typically rare.
Observation:
- A 50-year-old male with difficult-to-manage hypertension developed an ulcerative lip lesion.
- The patient was treated with candesartan cilexetil for uncontrolled hypertension.
- A lip biopsy confirmed erythema multiforme.
Findings:
- Candesartan cilexetil treatment led to marked blood pressure improvement.
- Erythema multiforme developed five weeks after initiating candesartan cilexetil.
- Discontinuation of candesartan cilexetil resulted in complete resolution of skin lesions.
Implications:
- This case suggests a potential link between candesartan cilexetil and drug-induced erythema multiforme.
- Clinicians should consider erythema multiforme in patients presenting with characteristic lesions while on candesartan cilexetil.
- This is the first reported instance of candesartan cilexetil-induced erythema multiforme.