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Progestins and place preference conditioning after paced mating.

Oscar González-Flores1, Francisco J Camacho, Emilio Domínguez-Salazar

  • 1Centro de Investigación en Reproducción Animal, CINVESTAV-Universidad Autónoma de Tlaxcala, Mexico.

Hormones and Behavior
|July 17, 2004
PubMed
Summary
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Female rats develop a reward state when pacing sexual interactions. Ring A-reduced progesterone metabolites, alongside progesterone, facilitate this reward state following paced mating.

Area of Science:

  • Neuroscience
  • Reproductive Biology
  • Behavioral Endocrinology

Background:

  • Sexual behavior in female rats can induce a reward state, measured by conditioned place preference (CPP).
  • Progesterone (P) is crucial for proceptive behavior and CPP induction.
  • The role of ring A-reduced progesterone metabolites in this reward state remains unclear.

Purpose of the Study:

  • To investigate if ring A-reduced progesterone metabolites are involved in the reward state induced by paced sexual interactions in female rats.

Main Methods:

  • Ovariectomized rats received estradiol benzoate and either progesterone, Megestrol acetate, 5 alpha-pregnan-20 dione, or 5 beta-pregnan-3 alpha-ol-20-one intravenously.
  • Rats were tested for paced mating behavior.
  • Conditioned place preference was assessed after mating.

Related Experiment Videos

Main Results:

  • Paced mating, following treatment with progesterone or its ring A-reduced metabolites, induced a significant change in preference.
  • Progestins administered alone did not induce CPP.
  • All tested progestins facilitated the reward state associated with paced mating.

Conclusions:

  • Progesterone and its ring A-reduced metabolites play a role in facilitating the reward state observed after paced sexual activity in female rats.
  • These findings contribute to understanding the neurobiological mechanisms of sexual reward.