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LPFG Biosensor for IL-6 Detection in Murine Serum Samples Associated with Ischemic Disease
Brenda Vertti-Cervantes1, Karina González-León2, Marcos García-Juárez3
1Instituto Politécnico Nacional, Centro de Investigación en Biotecnología Aplicada, Ex-Hacienda San Juan Molino Carretera Estatal Tecuexcomac, Tepetitla Km 1.5, Tlaxcala C.P. 90700, Mexico.
Sensors (Basel, Switzerland)
|May 13, 2026
Summary
Researchers developed a novel optical fiber biosensor using monoclonal antibodies to detect Interleukin-6 (IL-6), a key inflammatory protein. This advancement aids in diagnosing diseases like cerebral ischemic disease and monitoring treatment effectiveness.
Area of Science:
- Biomedical Engineering
- Optical Sensing
- Immunotechnology
Background:
- Optical fiber biosensors are crucial for medical diagnostics and treatment selection.
- Cerebral ischemic disease involves biomarkers indicating severity and progression.
- Interleukin-6 (IL-6) is an inflammatory protein linked to disease states.
Purpose of the Study:
- To develop a long-period fiber grating (LPFG) biosensor for detecting Interleukin-6 (IL-6).
- To utilize monoclonal antibodies (IL-6 mAb) as the biological recognition element.
- To characterize the biosensor fabrication and detection process.
Main Methods:
- Fabrication of an LPFG biosensor using standard single-mode optical fiber.
- Characterization via optical and electronic microscopy for morphological analysis.
- Micro-infrared spectroscopy for functional group identification.
- Principal Component Analysis (PCA) for experimental data analysis.
Main Results:
- Successful assembly and characterization of the LPFG biosensor.
- Demonstrated ability to detect the presence of IL-6.
- Insights gained into the biosensor fabrication and detection mechanisms.
Conclusions:
- The developed LPFG biosensor effectively detects IL-6, a significant inflammatory biomarker.
- The biosensor shows potential for applications in medical diagnostics, particularly for inflammatory and ischemic diseases.
- Characterization methods confirmed the biosensor's functionality and provided fabrication insights.
