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Protease inhibitors reduce the reverse passive Arthus reaction
Agents and Actions
|October 1, 1978
Summary
Certain inhibitors, including Trasylol and tranexamic acid, reduce vascular permeability and leucocyte influx during inflammatory reactions. These findings highlight potential therapeutic targets for managing inflammation and vascular leakage.
Area of Science:
- Pharmacology
- Immunology
- Vascular Biology
Background:
- The reverse passive Arthus reaction is an experimental model of acute immune complex-mediated inflammation.
- Vascular permeability and leucocyte infiltration are key features of this inflammatory response.
Purpose of the Study:
- To investigate the effects of various protease inhibitors on vascular permeability and leucocyte influx during an induced inflammatory reaction.
- To assess the potential of these inhibitors as therapeutic agents for inflammatory conditions.
Main Methods:
- Induction of a reverse passive Arthus reaction in rat skin and pleural cavity.
- Measurement of vascular permeability using 131I-albumin extravasation.
- Quantification of leucocyte influx into the pleural cavity.
Main Results:
- Trasylol, ovomucoid, tranexamic acid, and soybean inhibitor significantly decreased vascular permeability in the skin.
- Systemic administration of Trasylol suppressed the inflammatory reaction, comparable to phenylbutazone.
- Both Trasylol and tranexamic acid reduced leucocyte influx in the pleural cavity.
Conclusions:
- Protease inhibitors can effectively modulate key aspects of acute inflammatory responses.
- These agents demonstrate potential for mitigating vascular leakage and leucocyte recruitment in inflammatory diseases.