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Updated: Aug 23, 2026
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
Penetrating keratoplasty: indications over a 10 year period
N Al-Yousuf1, I Mavrikakis, E Mavrikakis
1Corneoplastic Unit and Eye Bank, Queen Victoria Hospital, East Grinstead, West Sussex RH19 3DZ, UK.
Aims:
To determine the indications for penetrating keratoplasty (PK) at the Corneoplastic Unit and Eye Bank, UK, a tertiary referral centre, over a 10 year period.
Methods:
Records of all patients who underwent PK at our institution between 1990 and 1999 were reviewed retrospectively. Of the 1096 procedures performed in this period, 784 records were available for evaluation (72%).
Results:
Regrafting was the most common indication, accounting for 40.9% of all cases. Keratoconus was the second most common indication (15%), followed by Fuchs' endothelial dystrophy (9.3%), pseudophakic bullous keratopathy (7.6%), and viral keratitis (5.9%), which included both herpes simplex and herpes zoster and showed a statistically significant decreasing trend using regression analysis (p<0.005). Among the regraft subgroup, viral keratitis accounted for 21.2% as the underlying primary diagnosis. The most common cause for graft failure in the regraft subgroup was endothelial failure (41.8%).
Conclusion:
Regrafting is the leading indication for PK; viral disease-although declining-is the leading primary diagnosis.
