[Alkaline phosphatase activity and bone isoenzymes in children treated with lithium]

The acute stage of manic depressive psychosis before the onset of lithiotherapy is characterized, similarly as the group of patients with the diagnosis of schizoaffective psychosis, by low levels of bone isoenzyme of alkaline phosphatase and normal values of alkaline phosphatase which in the course of lithium treatment decline markedly, similarly as in patients with unipolar manic depressive psychosis. The mentioned changes are very probably associated with changes of the extracellular calcium homeostasis. Schizophrenic patients do not have the described changes and the activities of AP and bone isoenzyme are the same before and after lithiotherapy.