Related Experiment Videos
[Steroid cataracts in children].
J Krásný1, V Kozáková, M Odehnal
1Dĕtská ocní klinika FN Motol a 2. LF UK, Praha.
Ceskoslovenska Pediatrie
|June 1, 1992
Summary
Long-term corticosteroid use in children undergoing chronic dialysis can lead to posterior subcapsular cataract (PSC). A daily dose of 0.3 mg/kg Prednisone or equivalent for one year increases PSC risk.
Area of Science:
- Ophthalmology
- Pediatrics
- Pharmacology
Context:
- Pediatric patients undergoing chronic dialysis for conditions like asthma, juvenile chronic arthritis, and leukemia.
- Long-term corticosteroid therapy is a common treatment modality in this cohort.
- Prevalence of posterior subcapsular cataract (PSC) was investigated in this population.
Purpose:
- To assess the incidence of posterior subcapsular cataract (PSC) in children on long-term corticosteroids for chronic dialysis.
- To identify risk factors associated with corticosteroid-induced PSC in pediatric patients.
- To establish a threshold for corticosteroid dosage and duration linked to PSC development.
Summary:
- Posterior subcapsular cataract (PSC) was diagnosed in 23% (23 out of 95) of children on long-term corticosteroids.
- The risk factor identified is the corticosteroid dose relative to body weight, not the absolute dose.
- PSC development is associated with a daily dose of 0.3 mg/kg Prednisone or equivalent for one year.
Impact:
- Highlights the risk of corticosteroid-induced PSC in pediatric patients on chronic dialysis.
- Recommends regular ophthalmic examinations for children on long-term corticosteroid treatment.
- Informs clinical practice regarding corticosteroid management in pediatric chronic diseases.