Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Encoding and retrieval in aging and memory loss, a fMRI study.

J Mandzia, S Black, C Grady

    Brain and Cognition
    |July 21, 2004
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    CT and MRI activity in England: insights from the diagnostic imaging dataset.

    Clinical radiology·2025
    Same author

    The accuracy of prehospital triage decisions in English trauma networks - a case-cohort study.

    Scandinavian journal of trauma, resuscitation and emergency medicine·2024
    Same author

    COVID-19 vaccines and adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals.

    Vaccine·2024
    Same author

    Recommended Resting-State fMRI Acquisition and Preprocessing Steps for Preoperative Mapping of Language and Motor and Visual Areas in Adult and Pediatric Patients with Brain Tumors and Epilepsy.

    AJNR. American journal of neuroradiology·2024
    Same author

    Cognitive decline in thrombotic thrombocytopenic purpura survivors: The role of white matter health as assessed by MRI.

    British journal of haematology·2023
    Same author

    Background rates of adverse events of special interest for COVID-19 vaccines: A multinational Global Vaccine Data Network (GVDN) analysis.

    Vaccine·2023
    Same journal

    Gelastic dysarthria: Speech-triggered pathological laughter with evidence for a selective pontine gating mechanism.

    Brain and cognition·2026
    Same journal

    Brain correlates of linguistic-cognitive stimulation in neurotypical and Atypical older adult populations: A systematic review.

    Brain and cognition·2026
    Same journal

    Effects of Dieting on Neural Encoding of Preferences for Edible and Non-Edible Rewards: An ERP Study.

    Brain and cognition·2026
    Same journal

    Structural complexity of brain regions in mild cognitive impairment and Alzheimer's disease.

    Brain and cognition·2026
    Same journal

    Spatial navigation training enhances performance on large-scale and small-scale spatial tasks through different neural mechanisms.

    Brain and cognition·2026
    Same journal

    Unraveling the link between brain injury and enhanced artistic skills.

    Brain and cognition·2026
    See all related articles

    Functional MRI (fMRI) detected distinct brain activation patterns in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) compared to normal controls (NC). These fMRI findings highlight potential differences in cognitive processing and disease progression.

    Area of Science:

    • Neuroscience
    • Cognitive Science
    • Medical Imaging

    Background:

    • Mild cognitive impairment (MCI) affects individuals with memory complaints exceeding normal age-related decline.
    • A subset of MCI patients progress to Alzheimer's disease (AD).
    • Functional MRI (fMRI) may offer enhanced sensitivity for detecting functional brain abnormalities in MCI.

    Purpose of the Study:

    • To investigate functional brain abnormalities in individuals with MCI using fMRI.
    • To compare fMRI activation patterns between MCI, AD, and normal controls (NC).
    • To explore the relationship between fMRI findings and behavioral performance during cognitive tasks.

    Main Methods:

    • fMRI scans were performed on four MCI patients, five age-matched NC, and one AD patient.

    Related Experiment Videos

  • Subjects completed incidental encoding (deep/shallow) and recognition tasks involving photographs.
  • Tasks were contrasted against a baseline fixation condition.

    • Main Results:

    • fMRI revealed significant dissociations in brain activation patterns between MCI/AD groups and NC.
    • Observed differences in activation patterns correlated with behavioral performance during cognitive tasks.
    • fMRI demonstrated potential for differentiating functional deficits associated with MCI and AD.

    Conclusions:

    • fMRI is a sensitive tool for identifying functional brain alterations in MCI and AD.
    • Distinct activation patterns observed via fMRI may indicate differing cognitive processing in MCI and AD.
    • fMRI findings suggest potential for early detection and monitoring of neurodegenerative conditions.