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Enantiomeric difference in percutaneous penetration of propranolol through rat excised skin
K Miyazaki1, F Kaiho, A Inagaki
1Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
Chemical & Pharmaceutical Bulletin
|April 1, 1992
Abstract:
The percutaneous penetration of R-(+)- and S-(-)-propranolol (PL) through rat excised skin was investigated in vitro. The flux of S-(-)-PL after application to normal skin was high compared with that of R-(+)-PL. On the other hand, in damaged rat skin, the flux of R-(+)-PL was almost equivalent to that of S-(-)-PL. It is suggested that there is an enantiomeric difference between S-(-)- and R-(+)-PL in terms of penetration through rat stratum corneum.