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Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
Endothelial lipase: a modulator of lipoprotein metabolism upregulated by inflammation
Uli C Broedl1, Weijun Jin, Daniel J Rader
1School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Abstract:
Both acute and chronic inflammatory states are associated with decreased levels of high-density lipoprotein (HDL) cholesterol, yet the underlying mechanism is poorly understood. Endothelial lipase (EL), a recently described member of the triglyceride lipase family, has been shown to be a key enzyme in HDL metabolism. Expression of EL by endothelial cells is upregulated by proinflammatory cytokines and is associated with increased EL-specific triglyceride and phospholipase activity in vitro. Thus, EL may play an important role in lipid metabolism and energy homeostasis in states of acute and chronic inflammation.
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